Top 9 Hydroxyapatite Toothpaste for a Flouride Alternative to Keeping your Teeth Clean & Healthy

Before we begin, please note hydroxyapatite toothpaste is a promising new option for oral care. However, we are not doctors and it’s important to talk to your dentist before making any changes to your oral care routine.

Have you heard of hydroxyapatite toothpaste as an alternative to flouride toothpaste? Traditional flouride toothpaste has been a mainstay in our oral care routines for decades. Crest released the first flourinated toothpaste in 1956. But, with the rise of natural and alternative health practices and products, a new player has entered the field: hydroxyapatite toothpaste.

What is Hydroxyapatite?

Hydroxyapatite (HA) is the main mineral that makes up tooth enamel, the hard outer layer of our teeth. It’s a biocompatible material, meaning it’s naturally compatible with the human body. It works hand-in-hand with our saliva to repair and rebuild the damaged enamel, making it stronger and more resistant to tooth decay. Because of all these reasons the National Aeronautics and Space Administartion (NASA) developed a hydroxyapatite based toothpaste for their astronauts who were losing mineral content in their bones and teeth from the lack of gravity. A Japanese company, Sangi Ltd., aquired the rights in 1970 and launched the first HA toothpaste to the public in the early nineties. From there, it is now available worldwide.

How Does Hydroxyapatite Toothpaste Work?

Tooth enamel, the protective layer on our teeth, takes a beating from acids, bacteria, and everyday wear and tear. Hydroxyapatite toothpaste actually contain Nano medical hydroxyapatite, mHAP, which are tiny particles of HA that can fill in microscopic scratches and imperfections in the enamel. This process, called remineralization (which is what flouride does as well), can help to:

  • Strengthen teeth: A stronger enamel means teeth are more resistant to cavities and erosion.
  • Reduce sensitivity: By filling in tubules in the dentin (the layer beneath the enamel), mHAP toothpaste can help to reduce sensitivity to hot and cold. It must be the nana version of Hydroxyapatite to be small enough to fit into the tubules and create remineralization. (Please note, from here on, when hydroxyapatite is mentioned in toothpaste we are referring to the nano version.)
  • Whiten teeth: mHAP is naturally white, so it can gently whiten teeth without the harsh abrasives found in some traditional whitening toothpastes.

Benefits of Hydroxyapatite Toothpaste

There are several potential benefits to using hydroxyapatite toothpaste:

  • Fluoride-free: For people who are concerned about fluoride or who have fluoride sensitivity, mHAP toothpaste is a good alternative.
  • Gentle on teeth: mHAP is a soft mineral, so it’s less abrasive than some traditional toothpastes. This is especially beneficial for people with sensitive teeth.
  • Natural ingredients: Many mHAP toothpastes are made with natural ingredients, such as xylitol and aloe vera.

The Cons or Downside of mHAP Toothpaste

As with any emerging product there are some additional things to keep in mind when considering hydroxyapatite toothpaste:

  • First, HA toothpaste can be more expensive than traditional toothpaste.
  • Also, the toothpaste may not be as widely available as traditional toothpaste.
  • Finally, there are some safety concerns as the toothpastes must use nano particles. The short answer, that you should investigate further if you are concerned, is that the shape and size of the nano particles matters. A lot. And, there is no requirement from brands to disclose the exact type of nano-hydroxyapatite that is being used. As such, brand trust is very important.

Hydroxyapatite Toothpaste Safety from the Brands

After the concerns about nano-hydroxyapatite particles became better known the Scientific Committee on Consumer Safety (SCCS) released a statement concerning the issue. Further, they clarified what they deem is safe for use in toothpaste and mouthwash. These are listed below in the email we sent to some of the major brands or via the link above. Bubble & Bee, a retailer of organic products free from harmful chemicals and based in the US, has a accounting of the issue that is easy to understand (especially, if you don’t have a science degree!).

Since nano-hydroxyapatite is such an interesting product we wanted to hear “from the horse’s mouth” which products adhere to the endorsed SCCS standard. As such, we sent the following email to the top brands in the industry, that sell in the United States. Following are their responses (we removed extranious greetings and salutations but the conent of their answers has not been modified and is directly quoted).

How did we choose the brands? We looked for brands that:
  • Are easy to access in the United States (and preferably made here),
  • Are well reviewed online or often recommended in related Facebook groups, and
  • Seem to be bonafide companies (not a hobby producer of natural goods) and have an online presence beyond Amazon.

Our Email to Toothpaste Brands

“We are putting together an article on nHA toothpastes and are trying to confirm if your brand conforms to the recent safety updates released by the EU (quoted below)?  And, if not, do you have an opinion or statement on those regulations in regard to your products.

SCCS – Final Opinion on Hydroxyapatite (nano)

Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash.  

This safety evaluation only applies to the hydroxyapatite (nano) with the following characteristics:

– composed of rod-shaped particles of which at least 95.8% (in particle number) have an aspect ratio less than 3, and the remaining 4.2% have an aspect ratio not exceeding 4.9;

– the particles are not coated or surface modified. 

As a mom who serves moms who serve their families this information is of great importance to all of us and we appreciate your help in clarifying these ingredients.”

Their Responses

“…, our n-Ha is an exception to the ban on nano materials, because of the shape and size of the molecule.”

We did not email them as they provide a statement prominently on their website: “We proudly uses nanoXIM by FLUIDNOVA in our products, the only nano-hydroxyapatite globally recognized and approved for oral care by the European Scientific Committee on Consumer Safety.”

“Yes, Davids nano-hydroxyapatite toothpaste products conform to the most recent guidance from the SCCS as you’ve detailed below.” 

“Yes, Duo toothpaste is made within the bounds of safety defined by the SCCS including concentration of 10% or less, rod-shaped particles (aspect ratio <3), and without coding or surface modification. The SCCS is of course a European entity, and while they endorse FLUIDINOVA based in Portugal, we source our nHA from Matexcel, a New York based materials science company with a longstanding history of supplying academia and industry. We use their dental remineralization specific nHA. 

We’re proud to include only the best and safest ingredients and to be the only tablet toothpaste in the United States formulated by dentists. “

“Yes, Dr. Jen’s toothpaste complies with the requirements of the Europen Commission.

Equally important for nHAp to work at fighting decay, the toothpaste requires a 10% nHAp concentration.  Most brands nano Hydroxyapatite brands are only adding 1 to 3%.  Without 10% concentration, the toothpaste can not provide an equivalent level of protection as fluoride. 

Particle size also needs to be nano.  “Micro” or “Hyrdoxyapattite” is 1,000 times too large and can not fit into the dentin tubules to allow phosphate and calcium uptake for effective remineralizng to occur. 

Dr. Jen’s is one of the only nano Hydroxyapatite brands using the full 10% nHAp required for proper cavity protection. 

Here is one of the clinical studies showing how 10% provides the optimal levels of remineralizng. 


“…our toothpaste does comply with almost all of the recommendations from the EU SCCS approval earlier last year. Our toothpaste contains 10% nano-hydroxyapatite that is rod-shaped, of which at least 95.8% (in particle number) have an aspect ratio less than 3, and the remaining 4.2% have an aspect ratio not exceeding 4.9, and our particles are coated or surface modified in any way. 

However, we do use nanoXIM by Fluidnova because, in our clinical testing, we have not found it to be any different or better than our current formulation. Our testing labs are certified by the American Dental Association, so we trust these results and trust the ADA’s judgment on clinical results. 

It is unfortunate that the SCCS did not conduct a comprehensive review of the majority of nano-HA sources and only focussed on one single brand (or has not yet, at least). We are encouraged to see that our toothpaste formula complies with nearly all of the attributes listed in the SCCS document and hope that they will soon conduct a more comprehensive and inclusive evaluation of other sources/brands of nano-HA so we can see how these compare. It is important to note that the SCCS did not say other nano-HA is unsafe; they said they did not evaluate any other brand of nano-HA.

We are not opposed to nanoXIM in any way and will continue to evaluate it as well as any regulated documentation about it as we continue to innovate on our products.

“Yes, that is the only source [FLUIDINOVA] that we use for our NHA and also our hydroxyapatite. Our formulation complies fully with the safety standards as laid out by the SCCS.”

“Yes, they conform to report.” 

Thanks for reaching out. We can confirm that our nHA conforms to the safety updates released by the EU.

Please let us know if you need any further details.

As we could not verify their compliace to SCCS standards we will not recommend them.

  • Chomp Toothpaste: No response from email sent to info@chomptoothpaste.com.
  • Dr. Brite: No response from email sent to team@drbrite.com.
  • Dr. Gabe: info@drgabe.com
  • Dr. Wolff Bioniq: info@dr-wolff.us
  • Duo Toothpaste: media@duotoothpaste.com &
  • Himalaya USA: No response from email sent to writetous@himalayausa.com.
  • IntelliWHITE: info@shopintelliwhite.com
  • Risewell: Our email sent to press@risewell.com was marked undeliverable.
  • Sangi (Premio): No response from email sent to info@sangi-co.com and
  • Winkwell: hello@winkwell.com

The Best Nano-Hydroxyapatite Toothpastes on the Market

Pastes are listed in alphabetical order.

Boka Nano (n-Ha) Toothpaste Whitening

Ingredients (Refresh Mint)

Glycerin, Water, Hydrated Silica, Sorbitol, Sodium Bicarbonate (Baking Soda), Hydroxyapatite (nano), Xanthan Gum, Xylitol, Cocos Nucifera (Coconut) Oil, Elettaria Cardamomum Seed Oil, Persea Gratissima (Avocado) Fruit Extract, Mangifera Indica (Mango) Fruit Extract, Mangifera Indica (Mango) Fruit Extract, Mangifera Indica (Mango) Fruit Extract, Camellia Sinensis (Tea) Leaf Extract, Illicium Verum (Anise) Oil, Mentha Piperita (Peppermint) Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Mentha Spicata (Spearmint) Leaf Oil, Aloe Barbadensis Leaf Juice, Stevia Rebaudiana Leaf Extract, Menthol, Dimethyl Sulfone, Sodium Lauroyl Sarcosinate.

What We Like
  • Lots of flavors beyond mint, which are kid-friendly, like Lemon Lavender, Coco Ginger, and Orange Cream.
  • Travel size available
  • Verified their mHAP aheres to the SCCS standards.

Carifree Gel 1100

Ingredients (Mint)

Active Ingredient: Sodium Fluoride, .24% (w/w)

Other Ingredients: Glycerin, Hydrated Silica, Hydrogenated Starch Hydrolysate (HSH), Hydroxyapatite, Hydroxyethyl Cellulose, Menthol, Natural Flavors, Polysorbate 20, Potassium Sorbate, Saccharin, Sodium Benzoate, Sodium Bicarbonate, Sodium Hydroxide, Sodium Lauryl Sulfate, Water, Xylitol

What We Like
  • For those who are not completely ready to go full nano-dydroxyapatite, they have a version with flouride too
  • Prioritzes maintaining a proper oral pH balance

David’s Premium Natural Toothpaste / Sensitive+Whitening w/ Nano-hydroxyapatite


calcium carbonate (limestone abrasive), vegetable glycerin, purified water, sodium bicarbonate (baking soda), xylitol (birch derived), hydrated silica, hydroxyapatite, sodium cocoyl glutamate, carrageenan (seaweed derived), mentha piperita (peppermint oil), mentha viridis (spearmint) leaf oil, pimpinella anisum (anise) seed extract, gaultheria procumbens (wintergreen) leaf oil, stevia (leaf extract).

What We Like
  • Aluminum tube is recycleable
  • Made in the USA with 98% US origin ingredients
  • Verified their mHAP aheres to the SCCS standards.
  • Offers a travel size
  • Tube is larger at 5.25oz., versus many competitors tubes of 4 oz.
  • May be found in brick and mortar stores like our local fave, HEB

duo toothpaste

Ingredients (Original – wild mint medley)

Nano-hydroxyapatite, xylitol (birch extract), calcium carbonate, sodium bicarbonate, cellulose, xanthham gum, magnesium sterate, hydrated silica, menthol, peppermint, wintergreen, spearmint, vitamin C, vitamin E.

What We Like
  • Glass botle packaging, plastic free
  • Options to focus on health goals like immunity, energy, and sleep
  • Verified their mHAP aheres to the SCCS standards.
  • Easy to travel with

Dr. Jen’s Remineralizing Toothpaste + 10% Nano-Hydroxyapatite


Aqua, Calcium Carbonate (helps remove stains and whiten teeth), Xylitol, Glycerin (soothes and moisturizes, derived from coconut), Silica (polishes teeth), Nano-Hydroxyapatite (strengthens enamel), Potassium Cocoate (foams paste from coconut oil), Cellulose Gum (thickens paste), Natural Flavor, Peppermint Oil, Spearmint Oil, Black Cherry (provides powerful antioxidants and reduces inflammation), Papaya (provides powerful antioxidants), Glycyrrhiza Glabra (flavors from licorice root), Citric Acid (preserves naturally), Spirulina (provides powerful antioxidants and coloring).

What We Like
  • Comprehensive response to our inquiry! Verified their mHAP aheres to the SCCS standards.

ELIMS Reflection Toothpaste

Ingredients (Lavender Vanilla)

Vegetable Glycerin, Xylitol, Deionized Water, Sorbitol, 10% Nano-Hydroxyapatite, Hydrated Silica, Sodium Methyl Cocoyl Taurate, Sodium Bicarbonate (Baking Soda), Natural Vanilla flavor, Cocos Nucifera (Coconut) Oil, Xanthan Gum, Calcium Carbonate, Benzoic Acid, Menthol (Mint), Chamomilla Recutita (Chamomile) extract, Lavandula Angustifolia (Lavender) Oil

What We Like
  • Verified their mHAP aheres to the SCCS standards.
  • Sustainable packaging made of sugar cane

Great Oral Health Nano hydroxyapatite Toothpaste

Ingredients (Wintermint)

Aloe Barbadensis Leaf Juice*, Xylitol, Calcium Carbonate, Hydroxyapatite, Hydrated Silica, Sodium Bicarbonate, Gaultheria Procumbens (Wintergreen) Oil, Sea Salt, Sodium Cocoyl Glutamate, Zinc Citrate, Bentonite, Cellulose Gum, Citric Acid, Zinc Gluconate, Melaleuca Alternifolia (Tree Tree) Oil, Glycerol, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara Fruit Extract, Citrus Aurantium Sinensis Peel Extract, Ascorbic Acid, Citric Acid, Lactic Acid, Aqua, Ammonium Glycyrrhizate, Tocopheryl Acetate, Magnasweet 100 (*Organic)

What We Like
  • Verified their mHAP aheres to the SCCS standards.
  • 99.9% glycerin free
  • Made in the USA

Huppy Peppermint Toothpaste Tablets


Xylitol, Natural Mint Flavor, Sodium Bicarbonate (Baking Soda), Calcium Carbonate, Sodium Cocoyl Isethionate (From Coconut), Hydroxyapatite (Nano), Caesalpinia Spinosa Gum, Silica, Zinc Citrate, Cocamidopropyl Betaine (From Coconut), Cellulose Gum, Cocos Nucifera (Coconut) Oil†, Mentha Piperita (Peppermint) Oil†, Melaleuca Alternifolia (Tea Tree) Leaf Oil†, Aloe Barbadensis Leaf Juice†, Mentha Arvensis (Menthol) Crystals†, Ammonium Glycyrrhizate (From Licorice Root). † Organic

What We Like
  • Verified their mHAP aheres to the SCCS standards.
  • Compostable or recyclable packaging with refills available.

Nudge Hydroxyapatite Toothpaste


Glycerin, Water, Hydrated Silica, Xylitol, Hydroxyapatite, Sodium Cocoyl Glutamate, Cellulose Gum, Mentha Piperita (Peppermint) Oil, Carrageenan, Citrus Paradisi (Grapefruit) Peel Oil, Cocos Nucifera (Coconut) Oil, Rebaudioside A, Titanium Dioxide, Eucalyptus Globulus Leaf Oil, Menthol

What We Like
  • Compared to the industry, currently it is a very affordable option
  • Packaging is recyclable, reusable, or compostable

Is Hydroxyapatite Toothpaste Right for You?

Hydroxyapatite toothpaste is deemed generally safe for most people. However, it’s important to talk to your dentist before using any new toothpaste, especially if you have any underlying oral health conditions.

Is hydroxyapatite part of your oral care routine?


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